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Science for Life: A Pill a Day Keeps HIV Away

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The Gladstone Institutes

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Partner:: Gladstone Institutes
Location:: UCSF Mission Bay Campus
San Francisco, CA
Event Date:: 06.23.11
Speaker:: Robert Grant
Tags:: hiv; aids; iPrEx

Summary: Can a pill prevent HIV? iPrEx, a large international study led by Gladstone Investigator Dr. Robert Grant, said “yes.” The study provided the first evidence that HIV infection can be prevented by a single daily tablet that combines two antiviral drugs. Time named the iPrEx study the #1 medical breakthrough of 2010.

Dr. Grant will describe these exciting findings and explain how they suggest a new strategy to help stop the HIV pandemic. The lecture will be followed by a panel discussion with leading experts in HIV prevention and a drag performance by Garza, a classically trained ballet dancer, choreographer, and LGBT activist.

Bio

Robert Grant

Dr. Robert Grant MD, MPH is the Gladstone Institute of Virology and Immunology Associate Professor of Medicine at University of California, San Francisco.

Chapters

: Watch Full Program

01 hr 09 min 55 sec

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01.: Introduction

02 min 12 sec

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02.: The HIV Pandemic

02 min 35 sec

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03.: Prevention Trial Disappointments

02 min 15 sec

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04.: Listening to Prior Success

02 min 40 sec

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05.: Global iPrEx Study

04 min 13 sec

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06.: Drugs Used in iPrEx and Placebo

03 min 34 sec

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07.: Did it Work?

01 min 48 sec

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08.: iPrEx OLE

01 min 42 sec

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09.: U.S. Approval

04 min 11 sec

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10.: Future Vision of PrEP

01 min 48 sec

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11.: Opportunities to Prevent HIV

01 min 24 sec

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12.: Impact of the Word 'Risk'

03 min 06 sec

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13.: Money and Investment

03 min 30 sec

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14.: Participants of Next Phase of Study

01 min 58 sec

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15.: Why Some People Did Not Take Pill

02 min 53 sec

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16.: Number of Participants

00 min 38 sec

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17.: Timeline for FDA Approval

00 min 56 sec

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18.: Panel Discussion

01 min 46 sec

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19.: Grant Colfax

05 min 15 sec

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20.: Dana Van Gorder

07 min 03 sec

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21.: Silver Cisneros

01 min 15 sec

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22.: Coinfection with Hepatitis B

02 min 15 sec

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23.: Limitations on Physicians Using PrEP

06 min 14 sec

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24.: AHF Against PrEP

04 min 38 sec

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: Watch Full Program

01 hr 09 min 55 sec

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iPrEx Study Finds New Drug Reduces HIV Infection

02 min 17 sec

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Gladstone Institute investigator Robert Grant presents encouraging results from the iPrEx study of Truvada, a pill for prevention of HIV infection. With findings of significantly reduced infections as compared to the placebo group, Grant announces the next phase will expand the study group.
Watch Full Program

01 hr 09 min 55 sec

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Encyclopædia Britannica Article

HIV: Retrovirus associated with AIDS. HIV attacks and gradually destroys the immune system, leaving the host unprotected against infection. It cannot be spread through casual contact but instead is contracted mainly through exposure to blood and blood products (e.g., by sharing hypodermic needles or by accidental needle sticks), semen and female genital secretions, or breast milk. A pregnant woman can pass the virus to her fetus across the placenta. The virus first multiplies in lymph nodes near the site of infection. Once it spreads through the body, usually about 10 years later, symptoms appear, marking the onset of AIDS. Multidrug “cocktails” can delay onset, but missing doses can lead to drug resistance. Like other viruses, HIV needs a host cell to multiply. It attacks helper T cells and can infect other cells. A rapid mutation rate helps it foil both the immune system and treatment attempts. No vaccine or cure exists. Abstinence from sex, use of condoms or other means to prevent sexual transmission of the disease, and avoidance of needle sharing have reduced infection rates in some areas.; HIV on britannica.com